Portrait of David M. Kushner
David M. Kushner, MD, FACOG
Professor, Vice Chair of Faculty Development, Education and Wellness, Co-Chair of Faculty Development, John and Jeanne Flesch Professor in Gynecologic Oncology
Gynecologic Oncology

Office Address

UW Hospital and Clinics
600 Highland Ave
Madison, WI, 53792

Clinic Address

Gynecology Oncology Clinic
600 Highland Ave
Madison, WI, 53705
Phone: 608-265-1700

Administrative Assistant

Dr. David Kushner is Vice Chair of Faculty Development, Education & Wellness and the tenured Flesch Professor of Gynecologic Oncology in the University of Wisconsin School of Medicine and Public Health Department of Obstetrics and Gynecology. Prior to this current role, he was Vice Chair of Clinical Research (2016-2022), building infrastructure across the Department to support and grow clinical trials. From 2006-2017, he directed the Gynecologic Oncology program at the UW Carbone Cancer Center (UWCCC). 

Dr. Kushner is an expert in the surgical and chemotherapeutic management of patients with gynecologic cancer. His research interest focuses on minimizing the negative impact of cancer and subsequent treatments on patients’ quality of life: sexual health after cancer, fertility/menopause-sparing surgery, postoperative pain management. To this end, he has been a U.S. pioneer for multiple innovative minimally invasive and fertility-sparing surgeries. He also helped found the Scientific Network on Female Sexual Health and Cancer, an international consortium of leading researchers dedicated to the scientific pursuit of improving sexual health for women after a cancer diagnosis. Dr. Kushner served as the International Chair of this network from 2014-2016. 

Dr. Kushner has worked to position UW as one of the nation’s premier institutions studying quality of life in gynecologic cancer. The UW environment offers outstanding collaborators such as the Center for Healthy Minds and the UW Health Women’s Integrative Sexual Health (WISH) clinic. Dr. Kushner was the founding Medical Director of the WISH clinic and helps oversee its research efforts. This program, along with the ongoing research in patient-reported outcomes, humor, and wellness, is positioning his group to apply for larger funding sources to study quality of life in gynecologic cancer. He is the primary investigator on multiple studies evaluating sexual health among gynecologic cancer survivors. Dr. Kushner has also acted as the Principal Investigator (PI) for NRG (formerly Gynecologic Oncology) at University of Wisconsin and Co-PI on the UWCCC institutional NIH Lead Academic Performance Site (LAPS) U10 grant. 

His interest in wellness runs beyond patients to the caregivers as well. He helped found and chaired the Society of Gynecology Oncology (SGO) Physician Wellness Taskforce. Locally, he founded and chaired the UW Department of Ob-Gyn Wellness Committee and acted as departmental representative for the UW Health Wellness Taskforce. He has researched and written seminal articles on burnout and wellness among cancer providers. 

Dr. Kushner was elected to the SGO Board of Directors. He also chairs the SGO’s State of the Society Survey, conducted every five years to provide detailed demographic and practice data that members can utilize to inform and support their clinical practices. He is an American Board of Obstetrics & Gynecology examiner for the oral gynecologic oncology board exam and has Chaired the American College of Obstetricians and Gynecologists (ACOG) PROLOG Taskforce for Gynecologic Oncology & Critical Care.

B.S. University of Michigan, Ann Arbor, MI
M.D. Wayne State University School of Medicine, Detroit, MI
Residency Northwestern University Medical School/ Prentice Women's Hospital, Chicago, IL
Fellowship The Cleveland Clinic Foundation, Cleveland, OH

American College of Obstetricians and Gynecologists 

Gynecologic Oncology

Vice Chair, Faculty Development, Education and Wellness

UW Health 2019 Clinical Educator Award 

Society of Gynecologic Oncology: State of the Subspecialty Survey, Co-Chair 

SSM Health/St Mary’s Foundation: Physician Guardian Angel Award 

PROLOG: Gynecologic Oncology & Critical Care, Task Force Co-Chair and Member 

Society of Gynecologic Oncology: Elected to the Board of Directors 

Mentor Training for Clinical and Translational Researchers,
UW Institute for Clinical and Translational Research 

The Ellen M. Hartenbach Award,
University of Wisconsin Department of Obstetrics & Gynecology 

Editorial Board – Gynecologic Oncology Case Reviews 

Society of Gynecologic Oncology: Wellness Taskforce, Founding Member and Co-Chair 

Leadership Development for Physicians in Academic Health Centers,
Harvard T.H. Chan School of Public Health

American College of Obstetricians and Gynecologists, Fellow 

Society of Gynecologic Oncology 

American Association of Gynecologic Laparoscopists 

American Society of Clinical Oncology 

Northwestern Obstetrical and Gynecological Society 

American Gynecologic & Obstetrical Society

Patient reported improvement in sexual health outcomes following care in a sexual health clinic for women with cancer

Joanne K Rash, Lori A Seaborne, Megan Peterson, David M Kushner, Janelle N Sobecki

CONCLUSION: Women with cancer report integrative sexual health care to address sexual problems that are helpful and result in long-term improvement. Patients are overall highly adherent to recommended therapies, and nearly all would recommend the program to others.

Published: 02/16/2023

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer pmid:36795172

Fluorescein Mapping in Vulvar Paget Disease

Matthew K Wagar, Ran Catherine Zhang, Paul Weisman, Ryan J Spencer, David M Kushner

CONCLUSION: We report a technique for the injection of fluorescein sodium for the visualization of vulvar Paget disease capable of providing accurate surgical margins and identification of occult satellite lesions with a high degree of safety and a favorable cost profile. This staged approach to vulvectomy could offer improved accuracy of resection for vulvar Paget disease with few drawbacks.

Published: 02/03/2023

Obstetrics and gynecology pmid:36735397

Obesity and "obesity-related" cancers: are there body mass index cut-points?

Jacqueline A Murtha, Natalie Liu, Jen Birstler, Bret M Hanlon, Manasa Venkatesh, Lawrence P Hanrahan, Tudor Borza, David M Kushner, Luke M Funk

CONCLUSIONS: BMI cut-points that accurately predicted development kidney and uterine cancer occurred in the overweight category. Analysis of multi-institutional EHR data may help determine if these relationships are generalizable to other health care settings. If they are, incorporation of BMI into the screening algorithms for these cancers may be warranted.

Published: 07/11/2022

International journal of obesity (2005) pmid:35817851

When we open and close: Postoperative outcomes after aborted primary cytoreduction for ovarian cancer

Connor C Wang, Matthew K Wagar, Amy Godecker, Ahmed Al-Niaimi, David M Kushner

CONCLUSIONS: Approximately one-third of patients will experience at least one G ≥ 3 complications after AD. Complications may be anticipated by low preoperative albumin. Patients can be counseled that, after AD, proceeding to subsequent NACT and ICS and achieving optimal debulking is common.

Published: 04/28/2022

Gynecologic oncology reports pmid:35478695

Prominent decidualization following progestin treatment for endometrial hyperplasia and carcinoma as a mimic of large residual tumor: A cautionary tale

Yang Hu, Ahmed N Al-Niaimi, Alain Cagaanan, Elizabeth A Sadowski, David M Kushner, Paul S Weisman, Stephanie M McGregor

CONCLUSIONS: Large mass lesions following progestin therapy may histologically consist of DS with little to no residual neoplastic disease, such that perceived tumor size does not necessarily reflect extensive residual disease, especially in pre-menopausal patients. Intraoperative gross assessment alone may lead to unnecessary lymphadenectomy and/or oophorectomy, but this can potentially be prevented by using frozen section.

Published: 04/05/2021

Gynecologic oncology reports pmid:33816740

Development, Implementation, and Patient Perspectives of the Women's Integrative Sexual Health Program: A Program Designed to Address the Sexual Side Effects of Cancer Treatment

Lori A Seaborne, Megan Peterson, David M Kushner, Janelle Sobecki, Joanne K Rash

CONCLUSION: The WISH program enhances comprehensive survivorship care of female cancer survivors. Women report they benefit from care for sexual issues after cancer treatments. Advanced practitioners working in oncology are uniquely positioned to educate themselves, take leadership roles in the development and implementation of programs, and provide care to women affected by sexual side effects after cancer.

Published: 02/08/2021

Journal of the advanced practitioner in oncology pmid:33552660

Benign ovarian thecoma with markedly elevated serum inhibin B levels mimicking adult granulosa cell tumor

Erica V Carballo, Kaley M Gyorfi, Aleksandar K Stanic, Paul Weisman, Christopher G Flynn, David M Kushner

CONCLUSION: This case demonstrates that inhibin B lacks specificity as a tumor marker for adult granulosa cell tumor, even at very high levels. Knowledge of benign alternative explanations for this finding can facilitate improved preoperative patient counseling. Pertinent literature is reviewed, with an emphasis on proposed hypotheses for inhibin overproduction.

Published: 11/18/2020

Gynecologic oncology reports pmid:33204793


Rowan Karaman, Jin Xu, Ross F Harrison, David M Kushner, Paul S Weisman, Yoram Shenker

CONCLUSION: Renin-secreting ovarian adult granulosa cell tumors are rare causes of hyperreninemia leading to hypertension and hypokalemia.

Published: 01/23/2020

AACE clinical case reports pmid:31967026

Uterine Cervical Sarcoma With a Novel RET-SPECC1L Fusion in an Adult: A Case Which Expands the Homology Between RET-rearranged and NTRK-rearranged Tumors

Paul S Weisman, Morgan Altinok, Erica V Carballo, David M Kushner, Jessica J F Kram, Marc Ladanyi, Sarah Chiang, Darya Buehler, Elizabeth L Dickson Michelson

No abstract

Published: 01/10/2020

The American journal of surgical pathology pmid:31917708

The Society of Gynecologic Oncology wellness curriculum pilot: A groundbreaking initiative for fellowship training

Taylor B Turner, David M Kushner, Abigail Ford Winkel, Gerald McGwin, Stephanie V Blank, Jeffery M Fowler, Kenneth H Kim, SGO Wellness Taskforce

CONCLUSIONS: A structured curriculum to promote wellness among gynecologic oncology fellows is feasible and was associated with observed decreased reported stress among fellows at participating programs. This curriculum addresses ACGME requirements regarding trainee well-being, and showed potential for more programmatic, nationwide implementation. Fellowship culture change was not directly measured, but may have been one of the most significant positive outcomes of the wellness program. Further...

Published: 01/09/2020

Gynecologic oncology pmid:31911007

Using simple radiologic measurements to anticipate surgical challenge in endometrial cancer: a prospective study

Ross F Harrison, Jeremiah E Mcnamara, Claire B Beaumont, Elizabeth A Sadowski, Richard J Chappell, Mian M Shahzad, Ryan J Spencer, Ahmed N Al-Niaimi, Lisa M Barroilhet, Stephen L Rose, David M Kushner

CONCLUSIONS: Simple linear measurements of visceral fat obtained from preoperative imaging are more predictive than body mass index alone in anticipating surgeon-reported operative difficulty. These easily obtained measurements may assist in preoperative decision making in this challenging patient population.

Published: 01/15/2019

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society pmid:30640690

Cancer overturned: Endometrioma mimicking granulosa cell tumor and the importance of FOXL2 analysis

Emily R Rosen, David M Kushner, Aparna M Mahajan, Cara R King

CONCLUSIONS: A somatic missense mutation in the FOXL2 gene is a sensitive molecular marker for AGCT. Mutation analysis can help distinguish malignant from benign pathology to provide appropriate treatment and disease surveillance.

Published: 12/12/2018

Gynecologic oncology reports pmid:30533478

Preoperative obstructive sleep apnea screening in gynecologic oncology patients

Ross F Harrison, Erin E Medlin, Chase B Petersen, Stephen L Rose, Ellen M Hartenbach, David M Kushner, Ryan J Spencer, Laurel W Rice, Ahmed N Al-Niaimi

CONCLUSION: The prevalence of obstructive sleep apnea or screening at risk for the condition is high among women presenting for surgery with a gynecologic oncologist. Providers should consider evaluating a patient's risk for obstructive sleep apnea in the preoperative setting, especially when risk factors for the condition are present.

Published: 05/25/2018

American journal of obstetrics and gynecology pmid:29792853

Abuse, cancer and sexual dysfunction in women: A potentially vicious cycle

Brittany F Lees, Taylor P Stewart, Joanne K Rash, Shirley R Baron, Stacy Tessler Lindau, David M Kushner

More than 30% of women have a history of abuse. Women with cancer may be at substantially increased risk for abuse, but this issue is rarely discussed in the course of oncology care. Women with a history of abuse who present for cancer care commonly have a high prevalence of co-morbid illness. Sexual dysfunction, a highly prevalent but under-recognized condition among women of all ages, is also more common among both women with a history of abuse and women with cancer. Although common after...

Published: 04/18/2018

Gynecologic oncology pmid:29661496

Interventions to Address Sexual Problems in People With Cancer: American Society of Clinical Oncology Clinical Practice Guideline Adaptation of Cancer Care Ontario Guideline

Jeanne Carter, Christina Lacchetti, Barbara L Andersen, Debra L Barton, Sage Bolte, Shari Damast, Michael A Diefenbach, Katherine DuHamel, Judith Florendo, Patricia A Ganz, Shari Goldfarb, Sigrun Hallmeyer, David M Kushner, Julia H Rowland

Purpose The adaptation of the Cancer Care Ontario (CCO) guideline Interventions to Address Sexual Problems in People With Cancer provides recommendations to manage sexual function adverse effects that occur as a result of cancer diagnosis and/or treatment. Methods ASCO staff reviewed the guideline for developmental rigor and updated the literature search. An ASCO Expert Panel ( Table A1 ) was assembled to review the guideline content and recommendations. Results The ASCO Expert Panel determined...

Published: 12/12/2017

Journal of clinical oncology : official journal of the American Society of Clinical Oncology pmid:29227723

Surgical outcomes among elderly women with endometrial cancer treated by laparoscopic hysterectomy: a NRG/Gynecologic Oncology Group study

Erin A Bishop, James J Java, Kathleen N Moore, Nick M Spirtos, Michael L Pearl, Oliver Zivanovic, David M Kushner, Floor Backes, Chad A Hamilton, Melissa A Geller, Jean Hurteau, Cara Mathews, Robert M Wenham, Pedro T Ramirez, Susan Zweizig, Joan L Walker

CONCLUSION: Laparoscopic staging for uterine cancer is associated with decreased morbidity in the immediate postoperative period in patients ≥60 years old. These results allow for more accurate preoperative counseling. A minimally invasive approach to uterine cancer staging may decrease morbidity that could affect long-term survival.

Published: 10/18/2017

American journal of obstetrics and gynecology pmid:29037481

A phase II evaluation of ixabepilone in the treatment of recurrent/persistent carcinosarcoma of the uterus, an NRG Oncology/Gynecologic Oncology Group study

Carolyn K McCourt, Wei Deng, Don S Dizon, Heather A Lankes, Michael J Birrer, Michele M Lomme, Matthew A Powell, James E Kendrick, Joel N Saltzman, David Warshal, Meaghan E Tenney, David M Kushner, Carol Aghajanian

CONCLUSION: In this cohort of women, single agent ixabepilone showed modest but insufficient clinical activity.

Published: 12/29/2016

Gynecologic oncology pmid:28029447

Stress and burnout among gynecologic oncologists: A Society of Gynecologic Oncology Evidence-based Review and Recommendations

Ilana Cass, Linda R Duska, Stephanie V Blank, Georgina Cheng, Nefertiti C duPont, Peter J Frederick, Emily K Hill, Carolyn M Matthews, Tarah L Pua, Kellie S Rath, Rachel Ruskin, Premal H Thaker, Andrew Berchuck, Bobbie S Gostout, David M Kushner, Jeff M Fowler

No abstract

Published: 08/31/2016

Gynecologic oncology pmid:27575910

Physical examination of the female cancer patient with sexual concerns: What oncologists and patients should expect from consultation with a specialist

Stacy Tessler Lindau, Emily M Abramsohn, Shirley R Baron, Judith Florendo, Hope K Haefner, Anuja Jhingran, Vanessa Kennedy, Mukta K Krane, David M Kushner, Jennifer McComb, Diane F Merritt, Julie E Park, Amy Siston, Margaret Straub, Lauren Streicher

Answer questions and earn CME/CNE Sexual concerns are prevalent in women with cancer or cancer history and are a factor in patient decision making about cancer treatment and risk-reduction options. Physical examination of the female cancer patient with sexual concerns, regardless of the type or site of her cancer, is an essential and early component of a comprehensive evaluation and effective treatment plan. Specialized practices are emerging that focus specifically on evaluation and treatment...

Published: 01/20/2016

CA: a cancer journal for clinicians pmid:26784536

Robotic surgery for early stage cervical cancer: Evolution and current trends

Erin E Medlin, David M Kushner, Lisa Barroilhet

The management of early stage cervical cancer often includes surgery in the form of radical hysterectomy, radical trachelectomy, or radical parametrectomy. Surgical techniques have evolved to include minimal invasive approaches, and more recently, to include robotic assisted techniques. This review highlights the evolution of surgical management of early cervical cancer and specifically explores robotic assisted radical hysterectomy, radical trachelectomy, radical parametrectomy, and the role of...

Published: 01/16/2016

Journal of surgical oncology pmid:26768315

Maintaining sexual health throughout gynecologic cancer survivorship: A comprehensive review and clinical guide

Laura B Huffman, Ellen M Hartenbach, Jeanne Carter, Joanne K Rash, David M Kushner

CONCLUSION: Oncology providers can make a significant impact on the QoL of gynecologic cancer survivors by addressing sexual health concerns. Simple strategies can be implemented into clinical practice to discuss and treat many sexual issues. Referral to specialized sexual health providers may be needed to address more complex problems.

Published: 11/12/2015

Gynecologic oncology pmid:26556768

Preoperative Pelvic MRI and Serum Cancer Antigen-125: Selecting Women With Grade 1 Endometrial Cancer for Lymphadenectomy

Elizabeth A Sadowski, Jessica B Robbins, Kristie Guite, Krupa Patel-Lippmann, Alejandro Munoz del Rio, David M Kushner, Ahmed Al-Niaimi

CONCLUSION: Preoperative MRI and CA-125 evaluation identified women for lymphadenectomy with a high NPV.

Published: 10/27/2015

AJR. American journal of roentgenology pmid:26496578

Diminished Utilization of in Vitro Fertilization Following Ovarian Transposition in Cervical Cancer Patients

Sana M Salih, Samet Albayrak, Songwon Seo, Sarah L Stewart, Kristen Bradley, David M Kushner

CONCLUSION: OT preserves menstrual cycle regularity without negatively impacting patients' quality of life. The utility of OT as an effective fertility preservation option is hampered by the low utilization rate of in vitro fertilization and lack of ovarian reserve assessment following OT.

Published: 09/19/2015

The Journal of reproductive medicine pmid:26380495

Sexual health education in U.S. physician assistant programs

Lori A Seaborne, Ronald J Prince, David M Kushner

CONCLUSIONS: PA programs in the United States appear to compare favorably with the training offered to medical students in regard to time spent on sexual health education. Transgender issues were least well-covered of all the topics queried.

Published: 04/10/2015

The journal of sexual medicine pmid:25856226

Uterine rupture disguised by urinary retention following a second trimester induced abortion: a case report

Qiaoying Jiang, Liwei Yang, Charles Ashley, Erin E Medlin, David M Kushner, Yanmei Zheng

CONCLUSION: This case highlights the difficulties in diagnosis of abnormal placentation and an unusual presentation of uterine rupture. This case was managed successfully laparoscopically.

Published: 01/23/2015

BMC women's health pmid:25608736

Intensive postoperative glucose control reduces the surgical site infection rates in gynecologic oncology patients

Ahmed N Al-Niaimi, Mostafa Ahmed, Nikki Burish, Saygin A Chackmakchy, Songwon Seo, Stephen Rose, Ellen Hartenbach, David M Kushner, Nasia Safdar, Laurel Rice, Joseph Connor

CONCLUSIONS: Initiating intensive glycemic control for 24h after gynecologic oncology surgery in patients with DM and postoperative hyperglycemia lowers the SSI rate by 35% (OR = 0.5) compared to patients receiving intermittent sliding scale insulin and to a rate equivalent to non-diabetics.

Published: 09/30/2014

Gynecologic oncology pmid:25263249

False positive PET-CT scan and clinical examination in a patient with locally advanced vulvar cancer

Latoya J Perry, Onur Guralp, Ahmed Al-Niaimi, Noah A Zucker, David M Kushner

► PET-CT scan was positive for metastasis of vulvar cancer to lymph nodes however they were histologically negative. ► Frozen section analysis should be performed at the time of surgery to confirm status of suspicious lymph nodes.

Published: 12/28/2013

Gynecologic oncology case reports pmid:24371671

Community screening leading to the diagnosis of androgen insensitivity syndrome at the age of 65

Alison M Gold, Noah A Zucker, Mian M K Shahzad, David M Kushner

No abstract

Published: 12/28/2013

Gynecologic oncology case reports pmid:24371658

Preoperative hypoalbuminemia is an independent predictor of poor perioperative outcomes in women undergoing open surgery for gynecologic malignancies

Shitanshu Uppal, Ahmed Al-Niaimi, Laurel W Rice, Stephen L Rose, David M Kushner, Ryan J Spencer, Ellen Hartenbach

CONCLUSION: Preoperative albumin levels <3g/dL identify a population of patients at a very high-risk of experiencing perioperative morbidity and 30-day mortality after open surgery.

Published: 08/22/2013

Gynecologic oncology pmid:23962700

A new diagnostic test for endometrial cancer?: Cytology analysis of sonohysterography distention media

Onur Guralp, Susan M Sheridan, Josephine Harter, James Louis Hinshaw, Songwon Seo, Ellen M Hartenbach, Steven Lindheim, Sarah Stewart, David M Kushner

CONCLUSIONS: Most patients with early endometrial cancer can undergo SIS procedures with adequate cytology specimens obtained from distention media. However, the sensitivity is low, and refinements are necessary before utilizing as a diagnostic test. In cases with positive results, the patient may be able to avoid other costly and painful procedures.

Published: 07/25/2013

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society pmid:23881100

Terpenoids from Zingiber officinale (Ginger) induce apoptosis in endometrial cancer cells through the activation of p53

Yang Liu, Rebecca J Whelan, Bikash R Pattnaik, Kai Ludwig, Enkateswar Subudhi, Helen Rowland, Nick Claussen, Noah Zucker, Shitanshu Uppal, David M Kushner, Mildred Felder, Manish S Patankar, Arvinder Kapur

Novel strategies are necessary to improve chemotherapy response in advanced and recurrent endometrial cancer. Here, we demonstrate that terpenoids present in the Steam Distilled Extract of Ginger (SDGE) are potent inhibitors of proliferation of endometrial cancer cells. SDGE, isolated from six different batches of ginger rhizomes, consistently inhibited proliferation of the endometrial cancer cell lines Ishikawa and ECC-1 at IC(50) of 1.25 µg/ml. SDGE also enhanced the anti-proliferative effect...

Published: 01/10/2013

PloS one pmid:23300887

The role of appendectomy for mucinous ovarian neoplasms

Jennifer E Lin, Songwon Seo, David M Kushner, Stephen L Rose

CONCLUSION: When a grossly normal appendix is removed during surgery for a mucinous ovarian neoplasm without evidence of pseudomyxoma peritonei, no primary or metastatic mucinous appendiceal tumors are found.

Published: 11/03/2012

American journal of obstetrics and gynecology pmid:23117124

Survivors of endometrial cancer: who is at risk for sexual dysfunction?

Nonyem Onujiogu, Tasha Johnson, Songwon Seo, Katherine Mijal, Joanne Rash, Lori Seaborne, Stephen Rose, David M Kushner

CONCLUSION: This patient population commonly thought to be at low risk actually suffers from severe sexual dysfunction. The four risk factors revealed by multivariate analysis need to be studied in greater detail in order to appropriately target patients and develop meaningful interventions.

Published: 08/23/2011

Gynecologic oncology pmid:21855974

Iatrogenic transtubal spill of endometrial cancer: risk or myth

Onur Guralp, David M Kushner

CONCLUSION: PPW rates vary between 0-14% after dilatation and curettage (D&C), 0-83% after H/S, 0-10% after L/S and 12-52% after SIS. The majority of the studies about EC cell dissemination during H/S and SIS suggest that they increase the risk of spill. There is not enough evidence to support the association between tumor spill and pressure, type and volume of distension medium, duration of the procedure, stage, grade and interval between H/S or SIS and laparotomy. Investigation into the rate...

Published: 08/13/2011

Archives of gynecology and obstetrics pmid:21837428

Uterine artery sparing robotic radical trachelectomy (AS-RRT) for early cancer of the cervix

Ahmed N Al-Niaimi, Margaret H Einstein, LaToya Perry, Ellen M Hartenbach, David M Kushner

CONCLUSION: Technically, the surgery is feasible and could be performed by any gynecologic oncologist who is skilled in radical pelvic surgery and the robotic system. The long-term obstetric and oncologic outcome of this technique would be expected to match the outcome of the other radical trachelectomy techniques in the published literature, but is yet to be fully elucidated.

Published: 10/16/2010

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics pmid:20947081

Effect of acetyl-l-carnitine on ovarian cancer cells' proliferation, nerve growth factor receptor (Trk-A and p75) expression, and the cytotoxic potential of paclitaxel and carboplatin

David B Engle, Jennifer A Belisle, Jennifer A A Gubbels, Sarah E Petrie, Paul R Hutson, David M Kushner, Manish S Patankar

CONCLUSION: ALCAR does not affect the cytotoxicity of paclitaxel or carboplatin. There was no increase in proliferation, or NGFR of OVCAR-3 or SKOV-3 cells exposed to ALCAR.

Published: 03/06/2009

Gynecologic oncology pmid:19263582

A protocol of dual prophylaxis for venous thromboembolism prevention in gynecologic cancer patients

M Heather Einstein, David M Kushner, Joseph P Connor, Alex A Bohl, Thomas J Best, Michael D Evans, Richard J Chappell, Ellen M Hartenbach

CONCLUSION: A protocol of dual prophylaxis with prolonged prophylaxis in high-risk patients was successfully implemented and was associated with a significant reduction in the rate of venous thromboembolism without increasing bleeding complications.

Published: 11/04/2008

Obstetrics and gynecology pmid:18978110

The effect of laparoscopic guidance on gynecologic interstitial brachytherapy

David B Engle, Kristin A Bradley, Rick J Chappell, Joseph P Conner, Ellen M Hartenbach, David M Kushner

CONCLUSION: The LAIB procedure appears safe, but substantially increases operating department time. No significant decrease in late high-grade toxicities were detected in comparison with TrIB. The LAIB procedure allows for both lysis of adhesions and identification of unknown carcinomatosis.

Published: 07/29/2008

Journal of minimally invasive gynecology pmid:18657479

Sonohysterography and endometrial cancer: incidence and functional viability of disseminated malignant cells

Emily Berry, Steven R Lindheim, Joseph P Connor, Ellen M Hartenbach, Julian C Schink, Josephine Harter, Jens C Eickhoff, David M Kushner

CONCLUSION: Transtubal spill occurs during sonohysterography. No critical spill volume was identified. A highly diagnostic tool when abnormal bleeding is evaluated, sonohysterography has a low probability of cancer cell dissemination.

Published: 05/06/2008

American journal of obstetrics and gynecology pmid:18456240

Laparoscopic sentinel lymph node mapping for cervix cancer--a detailed evaluation and time analysis

David M Kushner, Joseph P Connor, Michael A Wilson, G Reza Hafez, Richard J Chappell, Sarah L Stewart, Ellen M Hartenbach

CONCLUSIONS: Laparoscopic SLN mapping can be newly introduced into gynecologic oncology centers with high detection rates and negative predictive values. The visualization of blue dye in SLNs is transient, and this negative time correlation may explain the previously reported inferior detection rates with this technique. CLINICAL TRIAL REGISTRATION.: ClinicalTrials.gov, http://www.clinicaltrials.gov, NCT 00205010.

Published: 06/15/2007

Gynecologic oncology pmid:17560635

Weekly docetaxel and carboplatin for recurrent ovarian and peritoneal cancer: a phase II trial

David M Kushner, Joseph P Connor, Federico Sanchez, Michael Volk, Julian C Schink, Howard H Bailey, Linda S Harris, Sarah L Stewart, Jason Fine, Ellen M Hartenbach, Wisconsin Oncology Network

CONCLUSION: The weekly regimen of carboplatin and docetaxel has a good response rate with an acceptable toxicity profile.

Published: 01/30/2007

Gynecologic oncology pmid:17258800

Human telomerase RNA degradation by 2'-5'-linked oligoadenylate antisense chimeras in a cell-free system, cultured tumor cells, and murine xenograft models

Jayashree M Paranjape, Da Xu, David M Kushner, James Okicki, Daniel J Lindner, Hagen Cramer, Robert H Silverman, Douglas W Leaman

Ribonuclease L (RNase L) is a latent single-stranded RNA-directed endoribonuclease that is activated on binding to short 2'-5'-linked oligoadenylates (2-5A), a feature that has led to its use in antisense therapeutic strategies. By attaching a 2-5A moiety to the 5' terminus of standard antisense oligonucleotides, it is possible to activate RNase L and guide it to specific RNAs for degradation. These 2-5A antisense chimeras have been used successfully to target a variety of cellular and viral...

Published: 09/19/2006

Oligonucleotides pmid:16978086

Development and validation of a home-based, mirrored, gynecologic laparoscopy trainer

James K Robinson, David M Kushner

CONCLUSION: Home-based practice on a mirrored laparoscopy trainer improves hand-eye coordination in inexperienced surgeons and results in more frequent practice.

Published: 03/11/2006

Journal of minimally invasive gynecology pmid:16527711

Use of a bupivacaine continuous wound infusion system in gynecologic oncology: a randomized trial

David M Kushner, Regina LaGalbo, Joseph P Connor, Rick Chappell, Sarah L Stewart, Ellen M Hartenbach

CONCLUSION: The results suggest that although the continuous infusion system seems safe, it is not efficacious in this patient population.

Published: 08/02/2005

Obstetrics and gynecology pmid:16055569

Sonohysterography: a valuable tool in evaluating the female pelvis

Steven R Lindheim, Natalie Adsuar, David M Kushner, Elizabeth A Pritts, David L Olive

A number of medical conditions, including abnormal uterine bleeding, endometrial cancer, monitoring tamoxifen therapy, infertility, and recurrent abortion, warrant investigation of the female genital tract. Diagnostic studies including hysterosalpingogram, ultrasound, and sonohysterography have proved useful in the investigation of these gynecologic conditions. This article discusses each of these tests with particular emphasis on sonohysterography and their current and potential contributions...

Published: 10/29/2003

Obstetrical & gynecological survey pmid:14581828

Dr. Kushner's Research

Focus: Minimizing the negative impact of cancer and subsequent treatments on patients’ quality of life.

Edit profile